Invention Grant
- Patent Title: Octahydrocyclopentapyrroles, their preparation and use
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Application No.: US14775540Application Date: 2014-03-13
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Publication No.: US09637450B2Publication Date: 2017-05-02
- Inventor: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- Applicant: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2014/026818 WO 20140313
- International Announcement: WO2014/152018 WO 20140925
- Main IPC: C07D209/02
- IPC: C07D209/02 ; A61K31/454 ; C07D403/12 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D403/06 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; C07D209/52

Abstract:
The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.
Public/Granted literature
- US20160024007A1 OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE Public/Granted day:2016-01-28
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