Invention Grant
- Patent Title: Indole compound
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Application No.: US15109878Application Date: 2015-01-13
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Publication No.: US09637451B2Publication Date: 2017-05-02
- Inventor: Shunichiro Matsumoto , Takafumi Shimizu , Tomoyuki Saito , Takatoshi Kanayama , Hiroaki Tanaka , Chiharu Mori , Kazuhiro Yokoyama , Shigeo Matsui
- Applicant: ASTELLAS PHARMA INC.
- Priority: JP2014-004560 20140114
- International Application: PCT/JP2015/050691 WO 20150113
- International Announcement: WO2015/108039 WO 20150723
- Main IPC: C07D209/16
- IPC: C07D209/16 ; C07D403/12 ; C07D401/12 ; C07D417/12 ; C07D413/12

Abstract:
[Problem]To provide a compound useful as a MT1 and/or MT2 receptor agonist.[Solution]The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.
Public/Granted literature
- US20160332966A1 INDOLE COMPOUND Public/Granted day:2016-11-17
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