Invention Grant
- Patent Title: Fluorine substituted cyclic amine compounds and preparation methods, pharmaceutical compositions, and uses thereof
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Application No.: US14438457Application Date: 2013-10-17
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Publication No.: US09637454B2Publication Date: 2017-05-02
- Inventor: Hong Liu , Haiyan Zhang , Yu Zhou , Yan Fu , Hualiang Jiang , Xican Tang , Kaixian Chen
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MADICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MADICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Priority: CN201210418613 20121026
- International Application: PCT/CN2013/085356 WO 20131017
- International Announcement: WO2014/063587 WO 20140501
- Main IPC: C07D211/32
- IPC: C07D211/32 ; C07D405/06 ; C07D451/04 ; C07D211/38 ; A61K45/06 ; C07D211/34 ; C07D471/08 ; C07D491/107
Abstract:
The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular to compounds of general formula I, racemates, R-isomers, S-isomers, and pharmaceutically acceptable salts thereof and their mixtures, and the preparation methods thereof and a pharmaceutical composition containing the compounds and uses thereof as an acetylcholine esterase inhibitor.
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