Invention Grant
- Patent Title: Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
-
Application No.: US14436145Application Date: 2013-10-18
-
Publication No.: US09637491B2Publication Date: 2017-05-02
- Inventor: Michael Almstetter , Michael Thormann , Andreas Treml , Nadine Traube
- Applicant: Origenis GmbH
- Applicant Address: DE Martinsried
- Assignee: ORIGENIS GMBH
- Current Assignee: ORIGENIS GMBH
- Current Assignee Address: DE Martinsried
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/EP2013/003146 WO 20131018
- International Announcement: WO2014/060112 WO 20140424
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00 ; C07D487/04 ; C07D519/00
![Pyrazolo[4,3-D]pyrimidines as kinase inhibitors](/abs-image/US/2017/05/02/US09637491B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
Public/Granted literature
- US20150266882A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS Public/Granted day:2015-09-24
Information query
IPC分类: