Invention Grant
- Patent Title: Substituted 7-azabicycles and their use as orexin receptor modulators
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Application No.: US14774554Application Date: 2014-03-12
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Publication No.: US09637496B2Publication Date: 2017-05-02
- Inventor: Heather R. Coate , Curt A. Dvorak , Anne E. Fitzgerald , Terry P. Lebold , Cathy Preville , Brock T. Shireman
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: Baker & Hostetler LLP
- International Application: PCT/US2014/024322 WO 20140312
- International Announcement: WO2014/159591 WO 20141002
- Main IPC: C07D487/08
- IPC: C07D487/08 ; C07D519/00 ; C07D513/04 ; C07D471/04 ; A61K31/5377 ; A61K31/506 ; A61K31/444 ; A61K31/4439 ; A61K31/497 ; A61K31/498 ; A61K31/4709 ; A61K31/501 ; A61K31/4725 ; A61K31/496 ; A61K31/4985 ; A61K31/423

Abstract:
The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl; R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazoyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino; R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
Public/Granted literature
- US20160046640A1 SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS Public/Granted day:2016-02-18
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