Invention Grant
- Patent Title: Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
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Application No.: US14872487Application Date: 2015-10-01
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Publication No.: US09637499B2Publication Date: 2017-05-02
- Inventor: Simon Feldbaek Nielsen
- Applicant: LEO PHARMA A/S
- Applicant Address: DK Ballerup
- Assignee: LEO PHARMA A/S
- Current Assignee: LEO PHARMA A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D495/10 ; C07D493/10 ; A61K31/4427 ; A61K31/4433 ; A61K9/00 ; A61K31/443 ; A61K31/4436

Abstract:
Compounds of the general formula I wherein each of m and n is independently 0 or 1; R1 and R2, together with the carbon atom to which they are attached, form a heterocyclic ring comprising one or two heteroatoms selected from oxygen, sulfur, —S(O)— and —S(O)2—; R3 is —CHF2, —CF3, —OCHF2, —OCF3, —SCHF2 or —SCF3; X is a bond, —CH2—, or —NH—; A is aryl, cycloalkyl, cycloalkenyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkenyl, optionally substituted with one or more, same or different substituents selected from R4; and R4 is hydrogen, amino, thioxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, halogen, oxo, thia, or hydroxy; or pharmaceutically acceptable salts, hydrates or solvates thereof, have been found to exhibit PDE4 inhibiting activity, and may therefore be useful in the treatment of inflammatory diseases and disorders.
Public/Granted literature
- US20160022657A1 BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS Public/Granted day:2016-01-28
Information query
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