Invention Grant
- Patent Title: Controlled inhibition and re-activation of DNA polymerases by cleavable oligonucleotide inhibitors
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Application No.: US13914745Application Date: 2013-06-11
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Publication No.: US09637780B2Publication Date: 2017-05-02
- Inventor: Win D. Cheung , Jason A. Opdyke
- Applicant: HANWHA TECHWIN CO.,LTD.
- Applicant Address: KR Changwon-si
- Assignee: Hanwha Techwin Co., Ltd.
- Current Assignee: Hanwha Techwin Co., Ltd.
- Current Assignee Address: KR Changwon-si
- Agency: Sughrue Mion, PLLC
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34
Abstract:
A hot start enzyme composition is described that includes a hot start nuclease, a nucleic acid polymerase, and a substantially double-stranded oligonucleotide that inhibits the catalytic activity of the nucleic acid polymerase at temperatures lower than the melting temperature of the oligonucleotide.
Public/Granted literature
- US20130330734A1 CONTROLLED INHIBITION AND RE-ACTIVATION OF DNA POLYMERASES BY CLEAVABLE OLIGONUCLEOTIDE INHIBITORS Public/Granted day:2013-12-12
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