Systems and methods to generate a final event stream are provided. The system collects information from a wide variety of sources, and then parses, normalizes, and indexes the information. This generates an initial event stream that can be tagged and then iteratively processed to generate a final event stream. The processing includes first order logic querying and knowledge extraction to infer additional events which is added to the event stream. The final event stream is used by a knowledge exchange for consumption by applications. These applications may be internal applications and/or third party applications. This system may be particularly useful in use with medical information, or any other big data enterprise system.