A self refresh method with dithering has at least the following steps: generating a plurality of original frames; performing a dithering process upon the plurality of original frames to generate a plurality of dithering frames to a timing controller; checking if the plurality of original frames is unaltered; and when it is detected that the plurality of original frames is unaltered, requesting the timing controller to enter a self refresh mode, and stopping transmission of dithering frames after transmitting a specific frame and dithering information associated with the specific frame to the timing controller for further dithering processing.