Sense circuits, memory devices, and related methods are disclosed. A sense circuit includes sample and hold circuitry configured to sample and hold a second response voltage potential, a first response voltage potential, and a third response voltage potential responsive to an evaluation signal applied to a resistance variable memory cell. The sense circuit includes an amplifier operably coupled to the sample and hold circuitry. The amplifier is configured to amplify a difference between a sum of the first response voltage potential and the third response voltage potential, and twice the second response voltage potential. A memory device includes an evaluation signal generating circuit configured to provide the evaluation signal, an array of resistance variable memory cells, and the sense circuit. A method includes applying the evaluation signal to the resistance variable memory cell, sampling and holding the response voltage potentials, and discharging the sample and hold circuitry to the amplifier.