![Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide](/docs/US/2017-05-09/US09642799B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide
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Application No.: US14381289Application Date: 2013-03-13
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Publication No.: US09642799B2Publication Date: 2017-05-09
- Inventor: Rudy Laurent Maria Broeckx , Walter Ferdinand Maria Filliers , Patrick Hubert J Nieste , Alex Herman Copmans , Filip Marcel Vanhoutte , Carina Leys
- Applicant: Respivert Limited
- Applicant Address: GB Buckinghamshire
- Assignee: Respivert, Ltd.
- Current Assignee: Respivert, Ltd.
- Current Assignee Address: GB Buckinghamshire
- Agent Ada O. Wong
- International Application: PCT/GB2013/050624 WO 20130313
- International Announcement: WO2013/136076 WO 20130919
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D239/70 ; A61K9/00 ; C07D487/04 ; A61K47/12 ; A61K47/26 ; A61K31/52
![Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide](/abs-image/US/2017/05/09/US09642799B2/abs.jpg.150x150.jpg)
Abstract:
There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
Public/Granted literature
- US20150105408A1 CRYSTALLINE Pl3 KINASE INHIBITORS Public/Granted day:2015-04-16
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