Invention Grant
- Patent Title: Cationic lipids with various head groups for oligonucleotide delivery
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Application No.: US14876402Application Date: 2015-10-06
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Publication No.: US09642804B2Publication Date: 2017-05-09
- Inventor: Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
- Applicant: SIRNA THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick
- Main IPC: A61K9/00
- IPC: A61K9/00 ; C07J41/00 ; C07J43/00 ; A61K9/127 ; A61K31/7088
Abstract:
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
Public/Granted literature
- US20160113874A1 NOVEL CATATONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY Public/Granted day:2016-04-28
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