Invention Grant
- Patent Title: Treatment of B-cell lymphoma with microRNA
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Application No.: US14565049Application Date: 2014-12-09
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Publication No.: US09642872B2Publication Date: 2017-05-09
- Inventor: Vanessa Craig , Anne Mueller
- Applicant: University of Zurich
- Applicant Address: CH Zurich
- Assignee: UNIVERSITY OF ZURICH
- Current Assignee: UNIVERSITY OF ZURICH
- Current Assignee Address: CH Zurich
- Agency: Wilson Sonsini Goodrich & Rosati
- Priority: EP10182950 20100930
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K48/00 ; A61K31/7105 ; A61K31/7052 ; C12N15/113 ; A61K45/06
Abstract:
The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL.
Public/Granted literature
- US20150322430A1 TREATMENT OF B-CELL LYMPHOMA WITH MICRORNA Public/Granted day:2015-11-12
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