An orthopedic seat cushion for placement on a seat for supporting the weight of an occupant includes an envelope comprising an upper sheet and a lower sheet sealed together to define an interior volume. The interior volume is subdivided into a plurality of depressible cells wherein adjacent cells are in fluid communication with one another. The envelope has an opening penetrated through the upper sheet and lower sheet, wherein the opening has a front end and a back end and is configured to allow clearance for a sensitive area of the occupant. At least one cell has a height dimension that inhibits the sensitive area from contacting the seat when the at least one cell is depressed by the weight of the occupant.