Invention Grant
- Patent Title: Process for the preparation of bendamustine hydrochloride
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Application No.: US14576594Application Date: 2014-12-19
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Publication No.: US09643932B2Publication Date: 2017-05-09
- Inventor: Bhuwan Bhaskar Mishra , Nikunj Shambhubhai Kachhadia , Vinod Singh Tomar , Saswata Lahiri
- Applicant: Fresenius Kabi Oncology Limited
- Applicant Address: IN New Delhi
- Assignee: Fresenius Kabi Oncology Limited
- Current Assignee: Fresenius Kabi Oncology Limited
- Current Assignee Address: IN New Delhi
- Agency: Occhiuti & Rohlicek LLP
- Priority: IN2795/DEL/2011 20110926
- Main IPC: C07D235/16
- IPC: C07D235/16
Abstract:
The present invention relates to an improved process for the synthesis of bendamustine, in particular, bendamustine hydrochloride of the formula (VI) and its intermediate 1-methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazol-2-yl]lithium butanoate of formula (V), both having a purity of ≧99%, which is simple, convenient, economical, does not use hazardous chemicals and is industrially viable.
Public/Granted literature
- US20150105561A1 PROCESS FOR THE PREPARATION OF BENDAMUSTINE HYDROCHLORIDE Public/Granted day:2015-04-16
Information query
