Invention Grant
- Patent Title: Allosteric modulators of EGFR and constitutively active mutants
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Application No.: US14341529Application Date: 2014-07-25
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Publication No.: US09644002B2Publication Date: 2017-05-09
- Inventor: Alanna Schepartz
- Applicant: YALE UNIVERSITY
- Applicant Address: US CT New Haven
- Assignee: Yale University
- Current Assignee: Yale University
- Current Assignee Address: US CT New Haven
- Agency: Riverside Law LLP
- Main IPC: C07K7/08
- IPC: C07K7/08 ; A61K38/12 ; A61K38/10 ; C07K14/485 ; C07K7/54 ; C07K7/50
Abstract:
The present invention includes a novel class of allosteric modulators that target a protein having a juxtamembrane segment. In another embodiment, the allosteric modulator is a peptide mimetic that is capable of interacting with an α-helix or a coiled coil domain of a protein. In one embodiment, the peptide mimetic binds to at least an α-helix or a coiled coil domain of EGFR and modulates its activity.
Public/Granted literature
- US20150031612A1 Allosteric Modulators of EGFR and Constitutively Active Mutants Public/Granted day:2015-01-29
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