- Patent Title: Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody
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Application No.: US14567653Application Date: 2014-12-11
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Publication No.: US09644029B2Publication Date: 2017-05-09
- Inventor: Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahashi , Yasuko Kinoshita
- Applicant: Hiroyuki Aburatani , Perseus Proteomics Inc. , Chugai Seiyaku Kabushiki Kaisha
- Applicant Address: JP Tokyo JP Tokyo JP Tokyo
- Assignee: Hiroyuki Aburatani,Perseus Proteomics Inc.,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Hiroyuki Aburatani,Perseus Proteomics Inc.,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo JP Tokyo JP Tokyo
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: JP2004-102862 20040331; JP2004-227899 20040804; JP2005-004024 20050111
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; A61K39/00 ; G01N33/574 ; G01N33/576
Abstract:
A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
Public/Granted literature
- US20150291694A1 Cancer Diagnosis and Treatment of Cancer Using Anti-Robo 1 Antibody Public/Granted day:2015-10-15
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