Invention Grant
- Patent Title: Anti-RSPO2 antibodies and uses thereof
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Application No.: US14795811Application Date: 2015-07-09
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Publication No.: US09644034B2Publication Date: 2017-05-09
- Inventor: Austin L. Gurney , Fumiko Takada Axelrod , Timothy Charles Hoey , Cecile Chartier-Courtaud
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: ONCOMED PHARMACEUTICALS, INC.
- Current Assignee: ONCOMED PHARMACEUTICALS, INC.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein and Fox P.L.L.C.
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/30 ; G01N33/574 ; A61K45/06 ; C07K16/28 ; C07K16/46
Abstract:
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Public/Granted literature
- US20160002344A1 RSPO BINDING AGENTS AND USES THEREOF Public/Granted day:2016-01-07
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