Invention Grant
- Patent Title: Compositions and methods for modulating Tau expression
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Application No.: US14776561Application Date: 2014-03-14
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Publication No.: US09644207B2Publication Date: 2017-05-09
- Inventor: Frank Rigo , Susan M. Freier
- Applicant: Ionis Pharmaceuticals, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Ionis Pharmaceuticals, Inc. Patent Dept.
- International Application: PCT/US2014/029752 WO 20140314
- International Announcement: WO2014/153236 WO 20140925
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/70 ; C12N15/113 ; C12N5/00

Abstract:
Disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Also disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Such compounds and methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
Public/Granted literature
- US20160032285A1 COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION Public/Granted day:2016-02-04
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