Invention Grant
- Patent Title: AAV1-caspase gene therapy induced pyroptosis for the treatment of tumors
-
Application No.: US14169112Application Date: 2014-01-30
-
Publication No.: US09644215B2Publication Date: 2017-05-09
- Inventor: Gary J. Brenner , Xandra O. Breakefield , Giulia Fulci
- Applicant: THE GENERAL HOSPITAL CORPORATION
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K48/00 ; C12N15/86 ; C12N9/16
Abstract:
Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
Public/Granted literature
- US20140309288A1 GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS Public/Granted day:2014-10-16
Information query
IPC分类:
