Invention Grant
- Patent Title: Disease susceptibility
-
Application No.: US13503424Application Date: 2010-10-21
-
Publication No.: US09644240B2Publication Date: 2017-05-09
- Inventor: Rolandus Hendrikus de Rijk , Melanie Diane Klok , Edo Ronald de Kloet
- Applicant: Rolandus Hendrikus de Rijk , Melanie Diane Klok , Edo Ronald de Kloet
- Applicant Address: NL Leiden
- Assignee: Leiden University
- Current Assignee: Leiden University
- Current Assignee Address: NL Leiden
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Priority: EP09252465 20091022; GB1015071.2 20100910
- International Application: PCT/EP2010/006430 WO 20101021
- International Announcement: WO2011/047856 WO 20110428
- Main IPC: C12Q1/68
- IPC: C12Q1/68

Abstract:
Provided herein is a method of assessing the susceptibility of a subject to, or aiding the diagnosis of, an anxiety disorder or depression, the method including determining whether the subject has a haplotype including rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951 with respective alleles ‘+CT, ‘C’, ‘T’, ‘C’ and ‘C’. Also provided is a kit of parts or solid substrate for use in assessing the susceptibility of a subject to an anxiety disorder or depression, the kit including or the solid substrate having attached thereto one or more nucleic acid molecules that hybridize selectively to a genomic region encompassing any two or more SNPs selected from the group consisting of rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951, and/or that hybridize selectively to a genomic region encompassing two or more polymorphic sites in linkage disequilibrium with any one or more SNPs selected from rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951.
Public/Granted literature
- US20120208195A1 DISEASE SUSCEPTIBILITY Public/Granted day:2012-08-16
Information query