A wellhead pressure control fitting comprising a generally tubular Pressure Control Equipment (PCE) adapter configured to mate with pressure control equipment at a first adapter end, and with a receptacle inside a generally tubular pressure control assembly at a second adapter end. The pressure control assembly is configured to mate with a wellhead. Cooperating abutment surfaces form a high pressure seal when the second adapter end is compressively received into the receptacle. A plurality of cam locks on the exterior of the pressure control assembly rotate responsive to extension and retraction of the cam lock pistons. Cam lock rotation causes perimeter curvatures on the cam locks to bear down on corresponding curvatures on the second adapter end, which in turn compresses the second adapter end into the receptacle to form the seal. A locking ring may restrain the cam locks from rotation while the seal is enabled.