- Patent Title: Targeting phosphofructokinase and its glycosylation form for cancer
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Application No.: US14417889Application Date: 2013-08-19
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Publication No.: US09645151B2Publication Date: 2017-05-09
- Inventor: Linda C. Hsieh-Wilson , Wen Yi
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2013/055606 WO 20130819
- International Announcement: WO2014/028939 WO 20140220
- Main IPC: G01N33/574
- IPC: G01N33/574 ; C07K16/40
Abstract:
The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering cellular metabolism in favor of cancerous growth. Also provided are compositions comprising an agent that decreases glycosylation of phosphofructokinase 1 or increases phosphofructokinase 1 expression or activity.
Public/Granted literature
- US20150369809A1 TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER Public/Granted day:2015-12-24
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