A self-capacitive touch panel and a conductive layer structure thereof are provided. The conductive layer structure includes multiple rectangular first electrode patterns, multiple second electrode patterns and multiple peripheral wires correspondingly connected with the first electrode patterns and the second electrode patterns. The first electrode patterns are arranged in a matrix. Neighboring two rows of first electrode patterns have at least two second electrode patterns disposed therebetween, and the second electrode patterns located at a same row have widths gradually decreased or increased along row direction and thereby together form a rectangular shape as a whole. By the above described manner, the invention can accurately determine actual touch points.