Return oriented programming (ROP) attack prevention techniques are described. In one or more examples, a method is described of protecting against return oriented programming attacks. The method includes initiating a compute signature hardware instruction of a computing device to compute a signature for a return address and the associated location on the stack the return address is stored and causing storage of the computed signature along with the return address in the stack. The method also includes enforcing that before executing the return instruction using the return address on the stack, initiating a verify signature hardware instruction of the computing device to verify the signature matches the target return address on the stack and responding to successful verification of the signature through execution of the verify signature hardware instruction by the computing device, executing the return instruction to the return address.