A multi-mode receiver includes a channel decomposition module (e.g., a Rake receiver) for separating a received signal into multipath components, an interference selector for selecting interfering paths and subchannels, a synthesizer for synthesizing interference signals from selected sub channel symbol estimates, and an interference canceller for cancelling selected interference in the received signal. At least one of the channel decomposition module, the synthesizer, and the interference canceller are configurable for processing multi-mode signals.