A method and system configures a wireless communication device to support various radio frequency test modes. A controller determines whether an RF test cable is connected between test equipment and a test connector while a corresponding transceiver(s) is operating. In response to determining that the RF test cable is connected between test equipment and the test connector while the corresponding transceiver is operating, the controller provides an antenna tuner configuration(s) corresponding to the operating transceivers to support a test mode which, for example, can include any of a carrier aggregation (CA) test mode and a diversity transmission test mode. However, if the RF test cable is not connected between test equipment and the test connector while the corresponding transceiver(s) is operating, the controller determines an antenna tuner configuration corresponding to a normal/non-test device communication mode. The controller configures the antenna tuner(s) using the determined antenna tuner configuration(s).