Embodiments of the disclosure relate to activating an interference signal rejection filter path based on detection of an interference signal in a wireless distribution system (WDS). In this regard, in one aspect, a filter path selection circuit is configured to activate an interference rejection filter path configured to suppress a predefined interference signal when the predefined interference signal is detected in a received radio frequency (RF) signal. In another aspect, the filter path selection circuit is configured to detect the predefined interference signal by comparing a measured power level of the predefined interference signal against a predefined power threshold. By activating the interference rejection filter path to suppress the predefined interference signal based on detection of the predefined interference signal, it is possible to dynamically respond to the predefined interference signal that may randomly appear in the WDS, thus providing an enhanced overall RF performance in the WDS.