Invention Grant
- Patent Title: Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
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Application No.: US14829527Application Date: 2015-08-18
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Publication No.: US09649301B2Publication Date: 2017-05-16
- Inventor: Peter Crooks , Linda Dwoskin , Guangrong Zheng , Sangeetha Sumithran , David Allen , Zhenfa Zhang , Paul Lockman
- Applicant: University of Kentucky Research Foundation
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky Research Foundation
- Current Assignee: University of Kentucky Research Foundation
- Current Assignee Address: US KY Lexington
- Agency: Crowell & Moring LLP
- Main IPC: A61K31/439
- IPC: A61K31/439 ; A61K31/395 ; C07D471/16 ; C07D471/06
Abstract:
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
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