Invention Grant
- Patent Title: Liquid formulations for TNFR:Fc fusion proteins
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Application No.: US14443557Application Date: 2013-11-15
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Publication No.: US09649383B2Publication Date: 2017-05-16
- Inventor: Ramesh S. Kashi , Shona P. Patel , Sarita Mittal , Ashwin Basarkar , Shuai Shi
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US2013/070248 WO 20131115
- International Announcement: WO2014/078627 WO 20140522
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K47/26 ; A61K47/18 ; A61K47/12 ; A61K47/22 ; A61K47/02 ; C07K14/715

Abstract:
The invention provides stable liquid formulations for a recombinant biopharmaceutical protein comprising a soluble form of the human p75 TNF receptor fused to an Fe domain of a human immunoglobulin protein (TNFR:Fc). Typically, biopharmaceutical proteins such as monoclonal antibodies (mAbs) and immunoglobulin fusion proteins (e.g., immunoadhesion proteins) are produced by recombinant DNA technology in mammalian cell expression systems. In order to guarantee the reproducible clinical performance of a biopharmaceutical product, manufacturers have to deliver a product of consistent and reproducible quality.
Public/Granted literature
- US20150290325A1 LIQUID FORMULATIONS FOR TNFR:Fc FUSION PROTEINS Public/Granted day:2015-10-15
Information query
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