Invention Grant
- Patent Title: Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use
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Application No.: US14659251Application Date: 2015-03-16
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Publication No.: US09650422B2Publication Date: 2017-05-16
- Inventor: Gwong-Jen J. Chang , Wayne D. Crill
- Applicant: The United States of America as represented by the Secretary of the Dept.of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C07K14/005 ; C12N7/00 ; G01N33/569 ; A61K39/00
Abstract:
Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection.
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