Invention Grant
- Patent Title: Aptamers and diagnostic methods for detecting the EGF receptor
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Application No.: US14369398Application Date: 2012-12-28
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Publication No.: US09651556B2Publication Date: 2017-05-16
- Inventor: Chris Bock , Deborah Ayers , Malti P. Nikrad , Bharat Nathu Gawande , Jennifer C. Bertino , Weimin Sun , Charles M. Strom , Noh Jin Park
- Applicant: Quest Diagnostics Investments Incorporated , SOMALOGIC, INC.
- Applicant Address: US DE Wilmington US CO Boulder
- Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED,SOMALOGIC, INC.
- Current Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED,SOMALOGIC, INC.
- Current Assignee Address: US DE Wilmington US CO Boulder
- Agency: Foley & Lardner LLP
- International Application: PCT/US2012/072094 WO 20121228
- International Announcement: WO2013/102096 WO 20130704
- Main IPC: C12N15/11
- IPC: C12N15/11 ; G01N33/574 ; C12N15/115 ; C07H21/04

Abstract:
The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3′ cap. In some embodiments, the 3′ cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5′-end of the aptamer and the moiety is attached the 5′ end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.
Public/Granted literature
- US20150086996A1 APTAMERS AND DIAGNOSTIC METHODS FOR DETECTING THE EGF RECEPTOR Public/Granted day:2015-03-26
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