A method for interventional navigation using 3D contrast-enhanced ultrasound (CEUS) imaging includes acquiring a reference 3D CEUS volume and tracking information during a useful lifetime of a contrast enhancement agent administered to the anatomy. Real-time tracked tissue images are acquired during the interventional procedure. In addition, a corresponding CEUS multiplanar reconstruction (MPR) for at least one of the acquired real-time tracked tissue images is generated. At least one of the acquired real-time tracked tissue images is displayed along with the corresponding CEUS MPR. The displayed real-time tracked tissue image includes at least an image of the instrument within the desired portion of the anatomy and the CEUS MPR corresponds to the displayed real-time tracked tissue image. Thus, the contrast enhanced image information and tissue image information are concurrently display for the interventional navigation at least subsequent to the expiration of the contrast enhancement useful lifetime.