Invention Grant
- Patent Title: Recombinant measles virus expressing chikungunya virus polypeptides and their applications
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Application No.: US14430975Application Date: 2013-09-26
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Publication No.: US09655961B2Publication Date: 2017-05-23
- Inventor: Frederic Tangy , Samantha Brandler , Philippe Despres , Andre Habel
- Applicant: INSTITUT PASTEUR , Themis Bioscience GMBH , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: FR Paris AT Vienna FR Paris
- Assignee: INSTITUT PASTEUR,THEMIS BIOSCIENCE GMBH,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: INSTITUT PASTEUR,THEMIS BIOSCIENCE GMBH,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Paris AT Vienna FR Paris
- Agency: Arrigo, Lee & Guttman LLP
- Priority: EP12306176 20120927
- International Application: PCT/EP2013/070137 WO 20130926
- International Announcement: WO2014/049094 WO 20140403
- Main IPC: C07K14/02
- IPC: C07K14/02 ; A61K39/12 ; C07K14/005 ; C12N7/00 ; C12N15/86 ; A61K39/00 ; A61K38/00

Abstract:
The invention relates to recombinant Measles virus expressing Chikungunya virus polypeptides, and concerns in particular virus like particles (VLP) that contain envelope and capsid proteins of a Chikungunya virus at their surface. These particles are recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by Chikungunya virus.
Public/Granted literature
- US20150238592A1 RECOMBINANT MEASLES VIRUS EXPRESSING CHIKUNGUNYA VIRUS POLYPEPTIDES AND THEIR APPLICATIONS Public/Granted day:2015-08-27
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