Invention Grant
- Patent Title: Coated vaso-occlusive device for treatment of aneurysms
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Application No.: US14775078Application Date: 2014-03-12
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Publication No.: US09655999B2Publication Date: 2017-05-23
- Inventor: Christopher J. Bettinger , Michael Bruce Horowitz
- Applicant: Carnegie Mellon University
- Applicant Address: US PA Pittsburgh
- Assignee: Carnegie Mellon University
- Current Assignee: Carnegie Mellon University
- Current Assignee Address: US PA Pittsburgh
- Agency: The Webb Law Firm
- International Application: PCT/US2014/024158 WO 20140312
- International Announcement: WO2014/165023 WO 20141009
- Main IPC: A61F13/00
- IPC: A61F13/00 ; A61L29/08 ; A61L29/16 ; A61B17/12 ; A61K31/352 ; A61L29/14 ; A61M25/00 ; A61L31/06 ; A61L31/10 ; A61L31/16

Abstract:
A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence.
Public/Granted literature
- US20160051733A1 Coated Vaso-Occlusive Device for Treatment of Aneurysms Public/Granted day:2016-02-25
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