Invention Grant
- Patent Title: Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis
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Application No.: US14765913Application Date: 2014-01-16
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Publication No.: US09656949B2Publication Date: 2017-05-23
- Inventor: Markus Klein , Sven Lindemann
- Applicant: MERCK PATENT GMBH
- Applicant Address: DE Darmstadt
- Assignee: MERCK PATENT GMBH
- Current Assignee: MERCK PATENT GMBH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano and Branigan, P.C.
- Priority: EP13000592 20130206
- International Application: PCT/EP2014/000100 WO 20140116
- International Announcement: WO2014/121884 WO 20140814
- Main IPC: A61K31/519
- IPC: A61K31/519 ; A61K31/337 ; A61K31/415 ; A61K31/426 ; A61K31/4406 ; A61K31/451 ; A61K31/495 ; A61K31/4965 ; C07C237/22 ; C07D213/81 ; C07D213/82 ; C07D233/64 ; C07D241/12 ; C07D241/24 ; C07C233/83 ; C07D277/30 ; C07D277/56 ; C07D211/34 ; C07D213/40 ; C07D213/56 ; C07D305/08 ; A61K31/197 ; C07D211/66 ; C07D231/12 ; C07D295/215
Abstract:
The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ADAMTS5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.
Public/Granted literature
- US20150368188A1 SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS Public/Granted day:2015-12-24
Information query
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