Invention Grant
- Patent Title: Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
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Application No.: US15029882Application Date: 2014-09-19
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Publication No.: US09656996B2Publication Date: 2017-05-23
- Inventor: Zusheng Xu , Yangtong Lou
- Applicant: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
- Current Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Shanghai
- Agency: Millen White Zelano and Branigan, PC
- Agent John Sopp; Anthony Zelano
- Priority: CN201310485200 20131016
- International Application: PCT/CN2014/086914 WO 20140919
- International Announcement: WO2015/055071 WO 20150423
- Main IPC: C07D239/84
- IPC: C07D239/84 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D473/34 ; C07D473/32 ; C07D495/04 ; C07D487/04 ; A61K31/5377 ; A61K31/498 ; A61K31/635 ; A61K31/4985 ; C07D405/14

Abstract:
Disclosed are a fused heterocyclic compound, a preparation method therefor, a pharmaceutical composition, and uses thereof. The preparation method of the fused heterocyclic compound and/or the pharmaceutically acceptable salt thereof in the present invention comprises three synthesizing routes. The present invention also provides a pharmaceutical composition, containing one or more of the fused heterocyclic compound, the pharmaceutically acceptable salt, hydrates, solvent compounds, polymorphs and prodrugs thereof, and a pharmaceutically acceptable carrier. The present invention also relates to an application of the fused heterocyclic compound and/or the pharmaceutical composition in preparing kinase inhibitors and in preparing drugs for preventing and treating diseases related to kinase. The fused heterocyclic compound of the present invention has selective inhibition function on PI3K δ, and can be used for preparing drugs for preventing and treating cell proliferation diseases such as cancers, infections, inflammations, or autoimmune diseases.
Public/Granted literature
- US20160244432A1 FUSED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTCIAL COMPOSITION, AND USES THEREOF Public/Granted day:2016-08-25
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