Invention Grant
- Patent Title: Human domain antibodies against components of the human insulin-like growth factor (IGF) system
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Application No.: US14710875Application Date: 2015-05-13
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Publication No.: US09657096B2Publication Date: 2017-05-23
- Inventor: Dimiter S. Dimitrov , Weizao Chen
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61K39/395 ; C07K16/28 ; A61K39/00 ; C07K16/22 ; G01N33/74
Abstract:
Antibodies and antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as methods of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer, are described. A method of detecting the presence of IGF-1R or IGF-2 in a sample using the disclosed antibodies and antibody fragments is also described.
Public/Granted literature
- US20150246967A1 HUMAN DOMAIN ANTIBODIES AGAINST COMPONENTS OF THE HUMAN INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM Public/Granted day:2015-09-03
Information query
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