Invention Grant
- Patent Title: Peptide with safer secondary structure, peptide library, and production methods for same
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Application No.: US13990123Application Date: 2011-12-05
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Publication No.: US09657289B2Publication Date: 2017-05-23
- Inventor: Hiroaki Suga , Takashi Higuchi
- Applicant: Hiroaki Suga , Takashi Higuchi
- Applicant Address: JP Tokyo
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Tokyo
- Agency: Canady + Lortz LLP
- Agent Suzannah K. Sundby, Esq.
- Priority: JP2010-270958 20101203; JP2011-113527 20110520
- International Application: PCT/JP2011/078028 WO 20111205
- International Announcement: WO2012/074129 WO 20120607
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C12N15/10 ; C12P11/00 ; C12P21/02 ; C07K14/00 ; C07K1/107 ; C07K2/00 ; A61K38/00

Abstract:
An object of the invention is to provide a peptide having a stabilized secondary structure.The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one π bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.
Public/Granted literature
- US20130316910A1 Peptide with Safer Secondary Structure, Peptide Library, and Production Methods for Same Public/Granted day:2013-11-28
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