Invention Grant
- Patent Title: Modified oligonucleotides for telomerase inhibition
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Application No.: US14714732Application Date: 2015-05-18
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Publication No.: US09657296B2Publication Date: 2017-05-23
- Inventor: Sergei Gryaznov , Krisztina Pongracz
- Applicant: Geron Corporation
- Applicant Address: US CA Menlo Park
- Assignee: Geron Corporation
- Current Assignee: Geron Corporation
- Current Assignee Address: US CA Menlo Park
- Agency: Bozicevic, Field & Francis LLP
- Agent Glenn J. Foulds; Carol L. Francis
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07C233/18 ; A61K47/48 ; C07H21/02 ; C07H21/04
Abstract:
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
Public/Granted literature
- US20150376624A1 Modified Oligonucleotides for Telomerase Inhibition Public/Granted day:2015-12-31
Information query
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