Invention Grant
- Patent Title: Promoters for increased protein expression in meningococcus
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Application No.: US14375222Application Date: 2013-02-01
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Publication No.: US09657297B2Publication Date: 2017-05-23
- Inventor: Isabel Delany , Serafina Guadagnuolo
- Applicant: GlaxoSmithKline Biologicals SA
- Applicant Address: BE Rixensart
- Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee Address: BE Rixensart
- International Application: PCT/EP2013/052108 WO 20130201
- International Announcement: WO2013/133917 WO 20130808
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/74 ; C07K14/22 ; A61K39/095
Abstract:
New promoters are described to drive transcription in meningococcus e.g. for over-expression of protein antigens for retention in membrane vesicles. Modified porA promoters lack the wild-type poly-G sequence which can cause phase variation. Meningococcal rRNA-coding genes (e.g. for 16S rRNA) can be used to drive transcription of a protein-coding gene. These approaches can be used in combination.
Public/Granted literature
- US20150218566A1 PROMOTERS FOR INCREASED PROTEIN EXPRESSION IN MENINGOCOCCUS Public/Granted day:2015-08-06
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