Invention Grant
- Patent Title: Method to detect the onset and to monitor the recurrence of chronic graft versus host disease in transplantation patients
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Application No.: US13796344Application Date: 2013-03-12
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Publication No.: US09658228B2Publication Date: 2017-05-23
- Inventor: David B. Miklos , Bita Sahaf , Leonore A. Herzenberg
- Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland University Junior University
- Current Assignee: The Board of Trustees of the Leland University Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: McCarter & English LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C12N5/00 ; G01N33/569
Abstract:
The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
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