Systems and methods for immediate physical erasure of data in a memory system in response to a user command are disclosed. In one implementation, a memory system includes a non-volatile memory and a controller in communication with the non-volatile memory. The controller comprises a processor that is configured to receive from a host in communication with the memory system, a destruct command that indicates a user request to make the memory system inoperable. The processor is further configured to perform one or more operations to render the memory system inoperable in response to the destruct command received from the host.