In accordance with embodiments of the present disclosure, a method may include storing a system fingerprint of an information handling system, the system fingerprint comprising information associated with one or more information handling resources of the information handling system recorded during creation of the system fingerprint including information regarding a security seed, wherein the security seed comprises a value stored at a location of a non-transitory computer readable medium integral to an information handling resource of the one or more information handling resources. The method may also include during a verification mode, based on the information in the system fingerprint, determining whether potential tampering of the information handling system has occurred, and if potential tampering has occurred, issuing an alert indicating potential tampering with the information handling system.