Some demonstrative embodiments include apparatuses, devices, systems and methods of communicating a wireless transmission according to a Physical Layer scheme. For example, a wireless station may be configured to generate a frame including a header and a data portion, the header including a modulation and coding scheme (MCS) value of an Orthogonal Frequency Divisional Multiplexing (OFDM) Physical layer (PHY) scheme or a Low Power Single Carrier (LPSC) PHY scheme; modulate and encode the header according to a Single Carrier (SC) PHY scheme; modulate and encode the data portion according to the OFDM PHY scheme or the LPSC PHY scheme; and process transmission of the frame.