A method is provided in one example embodiment and includes receiving a reputation value based on a hash of a file making a network connection and on a network address of a remote end of the network connection. The network connection may be blocked if the reputation value indicates the hash or the network address is associated with malicious activity. In more specific embodiments, the method may also include sending a query to a threat analysis host to request the reputation value. Additionally or alternatively the reputation value may be based on query patterns in particular embodiments. In yet more specific embodiments, the network connection may be an inbound connection and/or an outbound connection, and the reputation value may be based on a file reputation associated with the hash and a connection reputation associated with the network address of the remote end of the network connection.