Invention Grant
- Patent Title: Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics
-
Application No.: US14902004Application Date: 2014-07-01
-
Publication No.: US09663545B2Publication Date: 2017-05-30
- Inventor: Jeannine Hess , Malay Patra , Gilles Gasser , Abdul Jabbar , Robin B. Gasser
- Applicant: UNIVERSITÄT ZÜRICH , THE UNIVERSITY OF MELBOURNE
- Applicant Address: CH Zurich AU Melbourne
- Assignee: UNIVERSITAT ZURICH,THE UNIVERSITY OF MELBOURNE
- Current Assignee: UNIVERSITAT ZURICH,THE UNIVERSITY OF MELBOURNE
- Current Assignee Address: CH Zurich AU Melbourne
- Agent Soroker Agmon Nordman
- Priority: EP13174551 20130701
- International Application: PCT/EP2014/064005 WO 20140701
- International Announcement: WO2015/000928 WO 20150108
- Main IPC: C07F15/00
- IPC: C07F15/00 ; C07F15/02 ; C07F17/02 ; C07F15/06 ; C07F13/00 ; A01N55/02

Abstract:
The invention relates to compounds characterized by a general formula (1), wherein X is a group described by a general formula —Kp—Fl—Kq—, wherein Fl is —C(═O)—, —C(═S)—, with l being 0 or 1, Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, Kq is a Cq-alkyl with q being 0, 1, 2, 3 or 4, and wherein n of R1n is 0, 1, 2, 3, 4 or 5, and each R1 independently from any other R1 is —C(═O)OR2, —C(═O)NR22, —C(═O)SR2, —C(═S)OR2, —C(NH)NR22, CN4H2, —NR22, —C(═O)R2, —C(═S)R2, —OR2, —SR2, —CF3, —OCF3, —SCF3, —SOCF3, —SO2CF3, —CN, —NO2, —F, —Cl, —Br or —I, with each R2 independently from any other R2 being a hydrogen or C1-C4 alkyl, and wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use in a method for treatment of infections by helminths.
Public/Granted literature
- US20160368939A1 ORGANOMETALLIC 2-CYANO-2-AMINOBENZOATE-PROPYL DERIVATES AND THEIR USE AS ANTHELMINTICS Public/Granted day:2016-12-22
Information query