Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics
Abstract:
The invention relates to compounds characterized by a general formula (1), wherein X is a group described by a general formula —Kp—Fl—Kq—, wherein Fl is —C(═O)—, —C(═S)—, with l being 0 or 1, Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, Kq is a Cq-alkyl with q being 0, 1, 2, 3 or 4, and wherein n of R1n is 0, 1, 2, 3, 4 or 5, and each R1 independently from any other R1 is —C(═O)OR2, —C(═O)NR22, —C(═O)SR2, —C(═S)OR2, —C(NH)NR22, CN4H2, —NR22, —C(═O)R2, —C(═S)R2, —OR2, —SR2, —CF3, —OCF3, —SCF3, —SOCF3, —SO2CF3, —CN, —NO2, —F, —Cl, —Br or —I, with each R2 independently from any other R2 being a hydrogen or C1-C4 alkyl, and wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use in a method for treatment of infections by helminths.
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