A method for enhancing at least one image within a series of images is provided. The method includes: selecting the series of images; upscaling each image within the series of images; selecting a reference image among the series of images; performing image registration to align series of images with the reference image; evaluating the series of aligned images for a subset of pixel locations that exhibit high cross-frame variation; performing learning processing to substantially reduce noise and exclude motion biases at the subset of pixel locations; performing pixel fusion from the series of aligned and processed images to produce the super-resolution reference image. A computer program product and an imaging system are disclosed.