Invention Grant
- Patent Title: Encapsulation of messenger RNA
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Application No.: US14790562Application Date: 2015-07-02
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Publication No.: US09668980B2Publication Date: 2017-06-06
- Inventor: Frank DeRosa , Shrirang Karve , Michael Heartlein
- Applicant: RaNA Therapeutics, Inc.
- Applicant Address: US MA Lexington
- Assignee: RaNA Therapeutics, Inc.
- Current Assignee: RaNA Therapeutics, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; A61K9/50 ; A61K9/127 ; A61K31/713
Abstract:
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a mRNA solution and a lipid solution, wherein the mRNA solution and/or the lipid solution are at a pre-determined temperature greater than ambient temperature.
Public/Granted literature
- US20160038432A1 ENCAPSULATION OF MESSENGER RNA Public/Granted day:2016-02-11
Information query
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