Invention Grant
- Patent Title: Use of naringenin in preparing drugs for preventing and/or treatment abdominal aortic aneurysm
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Application No.: US14901692Application Date: 2014-01-24
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Publication No.: US09669005B2Publication Date: 2017-06-06
- Inventor: Wei Kong , Qinghua Cui , Jingang Zheng , Ziyi Liu , Fang Yu
- Applicant: Peking University
- Applicant Address: CN Beijing
- Assignee: PEKING UNIVERSITY
- Current Assignee: PEKING UNIVERSITY
- Current Assignee Address: CN Beijing
- Agency: Knobbe Martens Olson & Bear, LLP
- Priority: CN201310264289 20130627
- International Application: PCT/CN2014/000093 WO 20140124
- International Announcement: WO2014/206056 WO 20141231
- Main IPC: A61K31/353
- IPC: A61K31/353

Abstract:
Naringenin is used for preparing products for preventing and/or treating abdominal aortic aneurysms. The products include drugs and/or health care products. The products were tested in two clinically associated abdominal aortic aneurysm disease models: using angiotensin II (1000 ng/kg/min) through subcutaneous submerging pump to induce ApoE knockout mice; and using calcium phosphate (0.5 M) to daub the abdominal aortas of locally induced C57 mice with abdominal aortic aneurysms. Experiments demonstrate that orally administered naringenin can significantly inhibit the onset and development of an abdominal aortic aneurysm in the CaPO4 daubed and AngII submerging pump induced mice. Thus, naringenin can be used in the treatment of patients with abdominal aortic aneurysms.
Public/Granted literature
- US20160367523A1 USE OF NARINGENIN IN PREPARING DRUGS FOR PREVENTING AND/OR TREATMENT ABDOMINAL AORTIC ANEURYSM Public/Granted day:2016-12-22
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